Novel nanotechnological approaches for treatment of skin-aging.

One of the essential organs and protective barricades, the skin, needs to be taken care of early. Skin is affected by several intrinsic and extrinsic factors, and despite their morphological and pathological differences, they have many molecular similarities. As of today, various mechanisms and theories have been recommended for aging, such as cellular anility, reduced proliferative tendency, reduction in length of telomere, mutations in DNA, theory of free radical generation, and many others. In today's society, skin health is often considered an important indicator of health, which has led to an increased demand for anti-aging products. However, numerous conventional cosmetics and phytocompounds (curcumin, Vitamin E, resveratrol) utilized in anti-aging products have inimical physical and chemical attributes, including insufficient chemical stability and inadequate skin penetration bound their effectuality after topical administration. So recently, new novel nanotechnological approaches for preventing skin aging, such as liposomes, niosomes, solid lipid nanoparticles, transferosomes, ethosomes, nanostructured lipid carriers, and carbon nanotubes, are being used. Hence, the field of cosmeceutical nanomaterials is rapidly evolving, and we can look forward to seeing a variety of innovative nanotechnology-based cosmetic products be a game-changer for this multi-million anti-aging cosmetic industry. • The most common factors that influence skin aging are UV exposure, chronological aging, loss of oil, and sweat glands. • Intrinsic factors (gene mutation, cellular metabolism, and hormonal factor) and extrinsic factors (UV rays, pollutants, chemicals, and toxins) contribute to skin aging. • Collagen fragmentation occurs due to matrix metalloproteinases and ROS generation, which alter the signaling pathways. • Innovative nanotechnological drug delivery systems hold great potential in treating aging. [ABSTRACT FROM AUTHOR]