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Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models.
- Source :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Jun2022, Vol. 18 Issue 6, p1177-1185, 9p
- Publication Year :
- 2022
-
Abstract
- Introduction: The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods: A total of 985 Spanish community‐dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi‐state Markov models were performed to characterize transitions between states through the dementia continuum. Results: The rate of reversion from MCI to NC was 11%. There were significant non‐modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion: Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15525260
- Volume :
- 18
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 157264972
- Full Text :
- https://doi.org/10.1002/alz.12448