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Discovery of 4‑Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy.

Authors :
Zhang, Jifa
Yang, Chengcan
Tang, Pan
Chen, Juncheng
Zhang, Dan
Li, Yang
Yang, Gaoxia
Liu, Yun
Zhang, Yiwen
Wang, Yuxi
Liu, Jie
Ouyang, Liang
Source :
Journal of Medicinal Chemistry; 5/12/2022, Vol. 65 Issue 9, p6803-6825, 23p
Publication Year :
2022

Details

Language :
English
ISSN :
00222623
Volume :
65
Issue :
9
Database :
Supplemental Index
Journal :
Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
156858053
Full Text :
https://doi.org/10.1021/acs.jmedchem.2c00135