PROTECTIVE EFFECT OF Commiphora gileadensis METHANOLIC EXTRACT IN MICE AGAINST ACETAMINOPHEN, GENTAMICIN, AND Nerium oleander ETHANOLIC EXTRACT TOXICITY.

Commiphora gileadensis is a small tree belonging to the Burseraceae family. Previously, it was used in the treatment of symptoms such as fever and cough. Recently, several studies showed that Commiphora gileadensis promoted antibacterial activity for many Gram-negative and Gram-positive organisms. Evaluation of antioxidant activity of Commiphora gileadensis methanolic extract on mice liver, heart and kidney after treatment with mixture of toxins. Forty Balb/c mice were randomly classified into four groups; normal control, Commiphora gileadensis, toxins, and Commiphora gileadensis + toxins. The weight of each mouse was obtained before the experiment began, after four weeks, and at the end of the experiment. After eight weeks, the blood samples were collected from each mouse for a complete blood count (CBC) as well as liver, kidney, and cardiac function tests. Moreover, the liver, kidney, and heart homogenates were obtained for the measurement of lipid peroxidation (LPO), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), catalase, and superoxide dismutase (SOD). Histopathological examination was done for the liver, heart, and kidney of each mouse. The Commiphora gileadensis group showed a significant increase in weight after four weeks and at the end of the experiment compared with the control group (p < 0.01). The liver and cardiac function test results were significantly reduced in the Commiphora gileadensis + toxins group compared with the toxin group (p < 0.05). Moreover, LPO levels significantly decreased in the Commiphora gileadensis + toxins group compared with the toxin group in the liver, kidney, and heart homogenates (p < 0.01 or p < 0.05), while GSH and GSH-Px significantly increased in the Commiphora gileadensis + toxins group compared with the toxin group (p < 0.01 or p < 0.05). A histopathological study showed that Commiphora gileadensis restores the normal morphology of the liver, kidney, and heart after treatment with a mixture of toxins. The Commiphora gileadensis methanolic extract restores liver, kidney, and cardiac function as well as their normal architecture after treatment with a mixture of toxins as a result of its antioxidant activity. Antioxidant activity of Commiphora gileaden-sis methanolic extract on mice treated with mixture of toxins (acetaminophen, gentamicin and Nerium oleander ethanolic extract). [ABSTRACT FROM AUTHOR]