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Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5- (un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents.
- Source :
- Pakistan Journal of Pharmaceutical Sciences; Mar2022, Vol. 35 Issue 2, p447-456, 10p
- Publication Year :
- 2022
-
Abstract
- The synthetic methodology was initiated by reacting 1,4-benzodioxane-6-amine (1) with 2-bromoacetyl bromide (2) in aqueous alkaline media under dynamic pH control to get compound 2,3-dihydro-1,4-benzodioxin-6-yl-2- bromoacetamide (3). In the subsequent reactions, a variety of un/substituted-benzoic acids (4a-k), through a succession of three steps, was converted into respective oxadiazole nucleophiles, 7a-k. Finally, the targeted molecules, 8a-k, were obtained by reacting 7a-k with electrophile 3 in an aprotic polar solvent. These compounds were corroborated by spectral characterization like IR, EI-MS, ¹H-NMR, and CHN analysis data. These molecules were screened for their antibacterial potential and most of them exhibited a potent activity. Moreover, their cytotoxicity was profiled through hemolytic activity and it was observed that majority of them was very modest in toxicity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1011601X
- Volume :
- 35
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Pakistan Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 155566623
- Full Text :
- https://doi.org/10.36721/PJPS.2022.35.2.REG.447-456.1