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Sex Differences in the Relationship Between Arterial Stiffness and Cognitive Function in Older Adults.
- Source :
- Journal of Stroke & Cerebrovascular Diseases; Jan2022, Vol. 31 Issue 1, pN.PAG-N.PAG, 1p
- Publication Year :
- 2022
-
Abstract
- <bold>Objective: </bold>To examine potential sex differences in the relationship between arterial stiffness and global cognitive function and executive functions.<bold>Methods: </bold>Baseline data from 80 older adults were included from two randomized controlled trials (NCT02669394 and NCT02737878). Arterial stiffness was measured by carotid-femoral pulse wave velocity (cf-PWV). Cognitive function assessment included global cognition (Mini-Mental State Examination [MMSE]) and executive functions (set shifting [Trail Making Test Part B minus A], inhibition [Stroop Test], and working memory [Verbal Digit Span Backwards Test]). Separate statistical models were constructed to assess the effect of cf-PWV on each cognitive outcome for females and males. Each statistical model controlled for Framingham cardiovascular disease risk score and education.<bold>Results: </bold>Higher cf-PWV was associated with impaired MMSE performance in males (β = -0.48; p = 0.018), but not females (p ≥ 0.389). For executive processes, higher cf-PWV was associated with impaired Trail Making Test Part B minus A (β = 0.56; p = 0.005) and Stroop Test (β = 0.59; p = 0.004) in males, but not in females (ps ≥ 0.108). cf-PWV was not significantly associated with Verbal Digit Span Forward minus Backward Test in males or females (ps ≥ 0.108).<bold>Conclusions: </bold>Arterial stiffness is more strongly associated with cognitive impairment in males than females. These results further elucidate the interplay between vascular health and cognitive function by providing support for sex-specific mechanisms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10523057
- Volume :
- 31
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Stroke & Cerebrovascular Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 154693904
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106175