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Contralateral parenchymal enhancement on MRI is associated with tumor proteasome pathway gene expression and overall survival of early ER+/HER2-breast cancer patients.

Authors :
Ragusi, Max A.A.
Bismeijer, Tycho
van der Velden, Bas H.M.
Loo, Claudette E.
Canisius, Sander
Wesseling, Jelle
Wessels, Lodewyk F.A.
Elias, Sjoerd G.
Gilhuijs, Kenneth G.A.
Source :
Breast; Dec2021, Vol. 60, p230-237, 8p
Publication Year :
2021

Abstract

To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients eligible for breast-conserving surgery included in a prospective observational cohort study (MARGINS). The contralateral parenchyma was segmented and CPE was calculated as the average of the top-10% delayed enhancement. Total tumor RNA sequencing was performed and gene set enrichment analysis was used to reveal gene expression pathways associated with CPE (N = 226) and related to overall survival (OS) and invasive disease-free survival (IDFS) in multivariable survival analysis. The latter was also done for the METABRIC cohort (N = 1355). CPE was most strongly correlated with proteasome pathways (normalized enrichment statistic = 2.04, false discovery rate =.11). Patients with high CPE showed lower tumor proteasome gene expression. Proteasome gene expression had a hazard ratio (HR) of 1.40 (95% CI = 0.89, 2.16; P =.143) for OS in the MARGINS cohort and 1.53 (95% CI = 1.08, 2.14; P =.017) for IDFS, in METABRIC proteasome gene expression had an HR of 1.09 (95% CI = 1.01, 1.18; P =.020) for OS and 1.10 (95% CI = 1.02, 1.18; P =.012) for IDFS. CPE was negatively correlated with tumor proteasome gene expression in early ER+/HER2-breast cancer patients. Low tumor proteasome gene expression was associated with improved survival in the METABRIC data. • Contralateral parenchymal enhancement on MRI was associated with tumor proteasome gene expression in ER+/HER2-breast cancer. • A high contralateral parenchymal enhancement was associated with a low proteasome gene expression in the breast cancer. • Low proteasome tumor gene expression was associated with improved survival in an independent patient cohort. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09609776
Volume :
60
Database :
Supplemental Index
Journal :
Breast
Publication Type :
Academic Journal
Accession number :
154244656
Full Text :
https://doi.org/10.1016/j.breast.2021.11.002