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Lipoprotein subtypes after testosterone therapy in transmasculine adolescents.
- Source :
- Journal of Clinical Lipidology; Nov2021, Vol. 15 Issue 6, p840-844, 5p
- Publication Year :
- 2021
-
Abstract
- • Men and women have different lipoprotein subclasses. • Men have lipoprotein subtype profiles that are more atherogenic than those of women. • Transmasculine adolescents have lipoprotein subtypes that are like cisgender males. Differences in lipoprotein-particle subclasses between men and women start in puberty and narrow after menopause, suggesting a role for sex steroids. In this cross-sectional cohort study, we examined lipoprotein subtype profiles in transmasculine adolescents treated with testosterone. Transmasculine adolescents (n = 17) had lipoprotein profiles that were similar to those of cisgender males (n = 33) and more atherogenic than those of cisgender females (n = 32), with higher concentrations of small low-density lipoprotein (LDL) particles (435 ± 222 nmol/L vs. 244 ± 163 nmol/L, p = 0.008) and lower concentrations of large high-density lipoprotein (HDL) particles (1.5 ± 1.3 μmol/L vs 2.7 ± 1.2 μmol/L, p = 0.003) when compared to cisgender females. Thus, testosterone appears to be a major contributor to differences in lipoprotein profiles, a surrogate for cardiovascular disease risk, between cisgender women and both transgender and cisgender men. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19332874
- Volume :
- 15
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Lipidology
- Publication Type :
- Academic Journal
- Accession number :
- 154215799
- Full Text :
- https://doi.org/10.1016/j.jacl.2021.09.051