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Observer Agreement of Vertebral Fracture Grading Using Dual Energy Absorptiometry Vertebral Fracture Assessment in Duchenne Muscular Dystrophy.

Authors :
Martin, Hannah
Joseph, Shuko
Shepherd, S.
Di Marco, Marina
Dunne, Jennifer
Horrocks, Iain
Ahmed, S. Faisal
Wong, Sze Choong
Source :
Journal of Clinical Densitometry; Oct2021, Vol. 24 Issue 4, p622-629, 8p
Publication Year :
2021

Abstract

Routine screening of the spine for vertebral fracture is recommended in the recent international standards of care for boys with Duchenne muscular dystrophy (DMD). Recent international consensus endorses the use of dual energy absorptiometry vertebral fracture assessment for identification of vertebral fractures in children, which could be used instead of spine radiographs. This study aims to evaluate the inter-observer agreement for vertebral fracture classification in boys with DMD, and the impact on clinical management. Dual energy absorptiometry vertebral fracture assessment and morphometric analysis in 39 boys was performed by a reader with no prior experience (R1) and 2 readers with experience (R2 and R3). Inter-observer concordance of vertebral fracture grading comparing R1 with R2 and R3 was substantial (Kappa 0.66, 95% CI 0.56, 0.76). Concordance between R2 and R3 was almost perfect (Kappa 0.93, 95% CI 0.89, 0.97) which did not lead to differences in clinical management. Grading by R1 in comparison to R2 and R3 would have led to change in management of 5/39 boys (13%), according to recent standards of care guidance. Structured education programme on identification of vertebral fractures should be explored to ensure consistency of reporting of this important health outcome measure in DMD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10946950
Volume :
24
Issue :
4
Database :
Supplemental Index
Journal :
Journal of Clinical Densitometry
Publication Type :
Academic Journal
Accession number :
153851972
Full Text :
https://doi.org/10.1016/j.jocd.2021.01.009