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Cytotoxic dammarane triterpenoids from the hydrolyzate of Gynostemma pentaphyllum.
- Source :
- Phytochemistry Letters; Dec2021, Vol. 46, p136-142, 7p
- Publication Year :
- 2021
-
Abstract
- [Display omitted] • Three undescribed triterpenoids with rare skeletons (1 - 3) were reported. • One unreported gypenoside (4) was isolated. • The absolute configurations were determined by ECD analysis. • Their antiproliferative effects were evaluated in a variety of cell lines. Three undescribed dammarane-type triterpenoids with rare carbon skeletons (1 - 3), together with one unreported gypenoside (4), were isolated from a acid hydrolysis product of Gynostemma pentaphyllum (Thunb.) Makino. Their molecular structures were elucidated via a combination of spectroscopic and spectrometric data, while the absolute configurations of compounds 1 , 2 and 4 were determined by electronic circular dichroism (ECD) analyse. Notably, compounds 1 - 3 possess a 19(10→1)abeo structural moiety in the A ring. Saponin 4 possesses an unusual cyclopentenone side chain. Compounds 1 , 2 and 4 were screened for their antiproliferative effects against HepG2, MCF-7 and DU145 cell lines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18743900
- Volume :
- 46
- Database :
- Supplemental Index
- Journal :
- Phytochemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 153679573
- Full Text :
- https://doi.org/10.1016/j.phytol.2021.10.009