New N-methyl-4-quinolone alkaloid and citrinin dimer derivatives from the sponge-derived fungus Penicillium sp. SCSIO 41303.

[Display omitted] • Five new compounds were isolated from the sponge-derived fungus Penicillium sp. SCSIO41303. • Extensive NMR spectroscopic analysis, ECD calculation and X-ray crystallography data were used to elucidate new structures. • Compounds 2 and 11 exhibited enzyme inhibition activity against PL with IC 50 values of 24.62 and 7.15 μg/mL, respectively. Four new N -methyl-4-quinolones (1 – 4) and a new citrinin dimer derivative (10) with fourteen known compounds (5 – 9 , 11 – 19) were isolated from the sponge-derived fungus Penicillium sp. SCSIO41303. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, electronic circular dichroism (ECD) calculation, and X-ray single-crystal diffraction. Most of the isolated compounds were evaluated for their cytotoxic, antibacterial, anti-virus, and enzyme inhibitory activities against acetylcholinesterase (AChE), and pancreatic lipase (PL). Compounds 2 and 11 exhibited enzyme inhibition activity against PL with IC 50 values of 24.6 and 7.2 μg/mL, respectively. Besides, compound 11 showed enzyme inhibition activity against AChE with IC 50 value of 16.5 μg/mL. Compound 15 showed moderate inhibition activities with 52.2% at the concentration of 50 μg/mL against PL and antibacterial activity against Staphylococcus aureus displaying diameter of about 10 mm. [ABSTRACT FROM AUTHOR]