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Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido.
- Source :
- Journal of Veterinary Medical Science; 2021, Vol. 83 Issue 10, p1526-1533, 8p
- Publication Year :
- 2021
-
Abstract
- Borna disease virus (BoDV) is a neurotropic virus that causes several infections in humans and neurological diseases in a wide range of animals worldwide. BoDV-1 has been molecularly and serologically detected in many domestic and wild animals in Japan; however, the genetic diversity of this virus and the origin of its infection are not fully understood. In this study, we investigated BoDV-1 infection and genetic diversity in samples collected from animals in Hokkaido between 2006 and 2020. The analysis was performed by focusing on the P region of BoDV-1 for virus detection. The presence of BoDV-1 RNA was observed in samples of brain tissue and various organs derived from persistently infected cattle. Moreover, after inoculation, BoDV-positive brains were isolated from neonatal rats. The gene sequences of the P region of BoDV obtained from the rat brain were in the same cluster as the P region of the virus isolated from the original bovine. Thus, genetic variation in BoDV-1 was extremely low. The phylogenetic analysis revealed that BoDV-1 isolates obtained in this study were part of the same cluster, which suggested that BoDV-1 of the same cluster was widespread among animals in Hokkaido. [ABSTRACT FROM AUTHOR]
- Subjects :
- BORNA disease virus
GENETIC variation
VIRUS diseases
CATTLE
DOMESTIC animals
RATS
Subjects
Details
- Language :
- English
- ISSN :
- 09167250
- Volume :
- 83
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Journal of Veterinary Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 153355347
- Full Text :
- https://doi.org/10.1292/jvms.21-0155