Evaluation of the salivary flow of patients undergoing conventional radiotherapy for head and neck cancer.

The purpose of this cross-sectional, quantitative study was to evaluate the salivary flow of 20 patients undergoing conventional 2-dimensional radiotherapy in the head and neck region. Unstimulated salivary flow was measured with the spitting technique. In addition, xerostomia was evaluated through the Eisbruch grading system and the Xerostomia Inventory (XI). The patients were evaluated 3 times: DO, before the first radiotherapy session; D17, after the 17th radiotherapy session; and D35, after the last radiotherapy session. Most of the patients in the present study were men (70%). The larynx was the most frequent site of cancer in this sample (45%). The most prevalent oral alteration during radiotherapy was odynophagia (75%). The analysis of subjective symptoms of xerostomia revealed no statistically significant differences (P = 0.059). However, statistically significant differences in the XI were found, with scores increasing from DO to D17 and D35 (P = 0.004). With regard to the objective symptoms of xerostomia, most patients started treatment in grade 1 and remained in the same category at the end of radiation. There was a slight increase in salivary volume during treatment, an atypical finding that can probably be explained by the use of low-level laser, which was applied to prevent oral mucositis in all of the patients. The mean total radiation dose (65 Gy) received by the patients in the present sample did not appear to influence the XI values or salivary volume. The data reinforced the subjective nature of xerostomia, which is not always related to hyposalivation. [ABSTRACT FROM AUTHOR]