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Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer.
Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer.
- Source :
- Biomedical Papers of the Medical Faculty of Palacky University in Olomouc; Sep2021, Vol. 165 Issue 3, p233-240, 8p
- Publication Year :
- 2021
-
Abstract
- The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12138118
- Volume :
- 165
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Biomedical Papers of the Medical Faculty of Palacky University in Olomouc
- Publication Type :
- Academic Journal
- Accession number :
- 152594176
- Full Text :
- https://doi.org/10.5507/bp.2021.042