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Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer.

Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer.

Authors :
Alberti, Giusi
Mazzola, Margherita
Gagliardo, Carola
Pitruzzella, Alessandro
Fucarini, Alberto
Giammanco, Marco
Tomasello, Giovanni
Carini, Francesco
Source :
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc; Sep2021, Vol. 165 Issue 3, p233-240, 8p
Publication Year :
2021

Abstract

The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host-micro-organism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
12138118
Volume :
165
Issue :
3
Database :
Supplemental Index
Journal :
Biomedical Papers of the Medical Faculty of Palacky University in Olomouc
Publication Type :
Academic Journal
Accession number :
152594176
Full Text :
https://doi.org/10.5507/bp.2021.042