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Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine.

Durable Remission of Chemotherapy-Refractory Myeloid Sarcoma by Azacitidine.

Authors :
Haruya Okamoto
Yuri Kamitsuji
Yukiko Komori
Nana Sasaki
Yasuhiko Tsutsumi
Akihiro Miyashita
Taku Tsukamoto
Shinsuke Mizutani
Yuji Shimura
Tsutomu Kobayashi
Nobuhiko Uoshima
Junya Kuroda
Source :
Tohoku Journal of Experimental Medicine; Jun2021, Vol. 254 Issue 2, p101-105, 5p
Publication Year :
2021

Abstract

Myeloid sarcoma is a rare disease entity of extramedullary myeloid neoplasm that can occur both as an initial isolated myeloid sarcoma without leukemic cell invasion in the peripheral blood and bone marrow, and as the secondary lesion of acute and chronic myeloid leukemias, myelodysplastic syndrome and chronic myeloproliferative neoplasms. Due to its rarity and its frequent emergence as the recurrent lesion after intensive systemic therapy, including allogeneic hematopoietic stem cell transplantation, the standard treatment has not been established for myeloid sarcoma. In this report, we presented an 84-year-old female patient with isolated myeloid sarcoma which progressed to myelodysplastic syndrome and systemic myeloid sarcoma despite various types of conventional anti-leukemic chemotherapies. However, the patient got a durable partial response by the monotherapy of azacitidine, a hypomethylating agent. She received thirteen courses of azacitidine therapy without progression. We discuss the possibility that hypomethylating agents are the novel effective and feasible therapeutic options for myeloid sarcoma, even in cases refractory to or relapsed after intensive systemic treatment. We also discuss the possible future development of hypomethylating agent-containing combinatory therapeutic strategy for myeloid sarcoma, given its direct anti-leukemic effect and immunomodulatory effect. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00408727
Volume :
254
Issue :
2
Database :
Supplemental Index
Journal :
Tohoku Journal of Experimental Medicine
Publication Type :
Academic Journal
Accession number :
151234364
Full Text :
https://doi.org/10.1620/tjem.254.101