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Urinary tract imaging in infants with spina bifida: a selective approach to a baseline DMSA.

Authors :
S, Cascio
Doyle, M.
Mahon, O.Mc
G, Kelly
Source :
Journal of Pediatric Urology; Jun2021, Vol. 17 Issue 3, p396.e1-396.e6, 1p
Publication Year :
2021

Abstract

There is no general agreement among paediatric urologists on how infants with spina bifida (SB) should be investigated after birth. Recently the EUA/ESPU guidelines have been published recommending a baseline DMSA scan in the first year of life and a Voiding Cystourethrogram (VCUG) or Videourodynamic (VUD) between the second and third month of life. The aim of this study was to evaluate the outcome of renal investigations in the first year of life in infants with SB to verify if an early DMSA scan is indicated in the management of this group of patients. All renal imaging, Renal and Bladder Ultrasound (RBUS), VCUGs, VUDs and DMSA were reviewed by two independent assessors to evaluate outcome. Seventy patients with spina bifida (40 girls) were enrolled between June 2015 and February 2020. An early VUD detected vesico-ureteral reflux (VUR) in 8/49 (16%) of patients. An early VUD also gave additional information on detrusor under or over activity, bladder trabeculation, end filling detrusor pressure (EFDP) and sphincteric incompetence. DMSA scan detected renal scarring in 4/68 (6%) patients. Three of these 4 patients had significant history of febrile UTIs while the fourth patient had grade 2 left sided VUR. The initial assessment of a newborn with myelodysplasia includes a Renal and Bladder Ultrasound during birth hospitalization. This study confirms the recently published EUA/ESPU guidelines on the management of neurogenic bladder in children and adolescents, which recommend a VUD or VCUG & Cystomanometry with Electromyogram (CMG) (if VUD not available) in the first 6–12 weeks of life. A selective approach to DMSA scan only in infants with SB who either had a febrile UTI or vesico-ureteric reflux would not have missed any scarring or dysplasia and would have saved 58 unnecessary nuclear scans. Summary Table DMSA scan distribution of RIVUR grading by kidney for 68 infants (135 kidneys, 68 left, 67 right). Table 1 RIVUR Grade No Pts (%) Lt Kidney Rt Kidney 0 (no kidney segment affected) 65 (96%) 66 (99%) 1 (1–2 segments affected) 2 (3%) 1 (1%) 2 (3–4 segments affected) 1 (1%) 0 3 (>4 segments affected) 0 0 4 (global atrophy) 0 0 [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14775131
Volume :
17
Issue :
3
Database :
Supplemental Index
Journal :
Journal of Pediatric Urology
Publication Type :
Academic Journal
Accession number :
150968232
Full Text :
https://doi.org/10.1016/j.jpurol.2021.02.004