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Usefulness of cardiac hormones for evaluating valvular disease in cynomolgus monkeys (Macaca fascicularis).

Authors :
PAI, Chungyu
NAKAYAMA, Shunya
ITO-FUJISHIRO, Yasuyo
KANAYAMA, Kiichi
MUNESUE, Yoshiko
SANKAI, Tadashi
YASUTOMI, Yasuhiro
KOIE, Hiroshi
AGEYAMA, Naohide
Source :
Journal of Veterinary Medical Science; 2021, Vol. 83 Issue 4, p716-723, 8p
Publication Year :
2021

Abstract

Nonhuman primates are commonly used as experimental animals due to their biological resemblance to humans. In patients with cardiac disease, the levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) tend to increase in response to cardiac damage, and they are thus used as indicators for the diagnosis of human heart failure. However, no reference values for ANP and BNP have been reported for heart disease in nonhuman primates. In this study, we recorded the age, sex, and body weight of 202 cynomolgus monkeys, and performed evaluations to assess the ANP and BNP levels, electrocardiography and echocardiography, and accordingly divided the monkeys into two groups: healthy monkeys and those with spontaneous cardiac disease. Statistical analysis was performed to determine the relationship of ANP and BNP with the factors of age, sex, and body weight. No significant relationship was found between the levels of ANP and BNP and the factors of age, sex, and body weight. However, both the ANP and BNP levels were significantly different between the healthy monkeys and monkeys with valvular disease. Similar to humans, the ANP and BNP levels tended to increase with the progression of cardiac disease in monkeys. Based on these results, we concluded that ANP and BNP are indicators of cardiac disease in nonhuman primates, and that this nonhuman primate cardiac disease model is applicable for cardiology research in humans. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09167250
Volume :
83
Issue :
4
Database :
Supplemental Index
Journal :
Journal of Veterinary Medical Science
Publication Type :
Academic Journal
Accession number :
150228715
Full Text :
https://doi.org/10.1292/jvms.20-0606