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Delineation of the genetic and clinical spectrum, including candidate genes, of monogenic diabetes: a multicenter study in South Korea.

Authors :
Cheon, Chong Kun
Lee, Yeoun Joo
Yoo, Sukdong
Lee, Jung Hee
Lee, Jeong Eun
Kim, Hyun Ji
Choi, Im Jeong
Choi, Yeonsong
Lee, Semin
Yoon, Ju Young
Source :
Journal of Pediatric Endocrinology & Metabolism; Dec2020, Vol. 33 Issue 12, p1539-1550, 12p
Publication Year :
2020

Abstract

Objectives: Monogenic diabetes includes a group of heterogeneous diabetes types. We aimed to identify the frequency, clinical and molecular features of monogenic diabetes in a Korean pediatric cohort. Methods: A retrospective cohort and multicenter study of Korean children suspected to have monogenic diabetes, managed by four pediatric endocrine centers in the southeast region of South Korea, from February 2016 to February 2020. We recruited 27 pediatric Korean patients suspected to have monogenic diabetes who had at least two of the following three criteria (age at diagnosis, family history, and clinical presentation). Targeted exome sequencing was conducted in these patients. The functional consequences of the variants were predicted by bioinformatics and protein structure analysis. Results: Molecular genetic analysis identified 16 patients (59.3%) with monogenic diabetes. We identified a total of eight unique variants, including five novel variants (HNF4A c.1088C>T, CEL c.1627C>T and c.1421C>T, PAX4 c.538+8G>C, INS c.71C>T). We also identified two potential candidate gene variants for monogenic diabetes, namely c.650T>C in the SLC2A2 gene and c.629G>A in the PTF1A gene. Other variants were identified in the WFS1and NPHP3 genes in two rare genetic disorders. Variant-positive individuals had a lower presence of autoantibody positivity at the time of diagnosis and higher glycosylated hemoglobin levels at last follow-up when compared to variant-negative patients (p<0.001 and p=0.029, respectively). Conclusions: These results further expand the spectrum of known variants as well as potential candidate gene variants associated with monogenic diabetes in Korea. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0334018X
Volume :
33
Issue :
12
Database :
Supplemental Index
Journal :
Journal of Pediatric Endocrinology & Metabolism
Publication Type :
Academic Journal
Accession number :
147548693
Full Text :
https://doi.org/10.1515/jpem-2020-0336