Characterizing Colorectal Patients with Microsatellite-Instability in Vietnam.

Background: Microsatellite-Instability (MSI) plays an important role for colorectal cancer prognosis and personalized treatment. Aims: This study aimed to examine the MSI prevalence in Vietnamese colorectal cancer patients, as well as identify associated factors with MSI. Methods and Material: This cross-sectional study was performed on colorectal cancer patients at the Hanoi Oncology Hospital. Clinical characteristics were obtained from medical records. Immunohistochemistry methods was used to detect MSI. Chi-squared test was applied to examine the difference in clinical variables between MSI and microsatellite-stability (MSS) groups. Results: Among 139 colorectal patients, 14.4% had MSI. Patients in MSI-group had significantly higher rates in following characteristics compared to MSS-group: tumors in ascending and transverse colon (75%), mucinous carcinoma (45%), badly differentiated (50%) tumors, and tumor-infiltrating lymphocytes (65.0%). Conclusion: Colorectal cancer with MSI had specific clinical and histopathological characteristics. Determining MSI condition in colorectal cancer is important given that it allows screening for Lynch syndrome, in addition to its role as a prognostic and predictor of chemotherapy response and immunotherapy. [ABSTRACT FROM AUTHOR]