Key advances and remaining challenges in childhood and adolescent tuberculosis.

Keywords: Tuberculosis; Children; Paediatric; Adolescents; Women; Pregnancy EN Tuberculosis Children Paediatric Adolescents Women Pregnancy 25 26 2 11/23/20 20201101 NES 201101 Tuberculosis (TB) remains the leading infectious disease killer on the planet. TB preventive therapy (TPT) is an effective measure to prevent disease progression after TB exposure or infection, mainly within the short-term when risk of disease progression is highest, but also to reduce the reservoir of infection from which future disease may arise [5]. In high incidence settings TB transmission frequently occurs outside the household and this should be acknowledged [6], but even if many infections are missed household exposure offers an excellent opportunity for intervention given that TB services are already engaged with the family. [Extracted from the article]