Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors.

A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their α -glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC 50 74.0 ± 1.3 μmol·L⁻¹) than acarbose. The molecular docking revealed that compound 10f could bind to α -glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α -glucosidase inhibitors. [ABSTRACT FROM AUTHOR]