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Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts.
- Source :
- Food Bioscience; Aug2020, Vol. 36, pN.PAG-N.PAG, 1p
- Publication Year :
- 2020
-
Abstract
- To evaluate the phenolic profile and biological activity of the Algerian Sahara plant Acacia tortilis (Forssk.) Hayne ssp. raddiana decoction and 80% ethanolic extracts were studied. Chromatographic profiling indicated the presence of 36 phenolic compounds, including gallic acid esterified derivatives, galloylquinic derivatives and flavan-3-ols galloyl derivatives. Both extracts showed significant cytotoxic activity and a potent anti-inflammatory activity. They were effective against several multi-drug resistant bacteria, namely methicillin-resistant Staphylococcus aureus (MRSA). To understand the possible mechanism of action of MRSA inhibition activity, an in silico docking analysis was done using a virtual library of the 36 determined phenolic compounds against penicillin-binding protein (PBP2a), a protein known to be involved in MRSA resistance to β-lactam antibiotics. A. tortilis extracts showed interesting biological activities and the phenolic compounds found could be an interesting starting point for the development of cytotoxic and anti-inflammatory drugs and especially anti-MRSA antibiotics. Image 1 • Acacia tortilis decoction and ethanol extracts were characterized. • Esterified gallic acids, galloylquinic acids and flavan-3-ols galloyl derivatives were found. • Both extracts showed cytotoxic, anti-inflammatory and antibacterial activity. • Docking predicted PBP2a as a potential protein target for the phenolic compounds. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124292
- Volume :
- 36
- Database :
- Supplemental Index
- Journal :
- Food Bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 144583620
- Full Text :
- https://doi.org/10.1016/j.fbio.2020.100616