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Placental MRI: Effect of maternal position and uterine contractions on placental BOLD MRI measurements.
- Source :
- Placenta; Jun2020, Vol. 95, p69-77, 9p
- Publication Year :
- 2020
-
Abstract
- <bold>Introduction: </bold>Before using blood-oxygen-level-dependent magnetic resonance imaging (BOLD MRI) during maternal hyperoxia as a method to detect individual placental dysfunction, it is necessary to understand spatiotemporal variations that represent normal placental function. We investigated the effect of maternal position and Braxton-Hicks contractions on estimates obtained from BOLD MRI of the placenta during maternal hyperoxia.<bold>Methods: </bold>For 24 uncomplicated singleton pregnancies (gestational age 27-36 weeks), two separate BOLD MRI datasets were acquired, one in the supine and one in the left lateral maternal position. The maternal oxygenation was adjusted as 5 min of room air (21% O2), followed by 5 min of 100% FiO2. After datasets were corrected for signal non-uniformities and motion, global and regional BOLD signal changes in R2* and voxel-wise Time-To-Plateau (TTP) in the placenta were measured. The overall placental and uterine volume changes were determined across time to detect contractions.<bold>Results: </bold>In mothers without contractions, increases in global placental R2* in the supine position were larger compared to the left lateral position with maternal hyperoxia. Maternal position did not alter global TTP but did result in regional changes in TTP. 57% of the subjects had Braxton-Hicks contractions and 58% of these had global placental R2* decreases during the contraction.<bold>Conclusion: </bold>Both maternal position and Braxton-Hicks contractions significantly affect global and regional changes in placental R2* and regional TTP. This suggests that both factors must be taken into account in analyses when comparing placental BOLD signals over time within and between individuals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01434004
- Volume :
- 95
- Database :
- Supplemental Index
- Journal :
- Placenta
- Publication Type :
- Academic Journal
- Accession number :
- 143640888
- Full Text :
- https://doi.org/10.1016/j.placenta.2020.04.008