Diagnosis of Alzheimer's disease using universum support vector machine based recursive feature elimination (USVM-RFE).

• Proposed a universum based recursive feature selection technique. • Feature selection is performed using knowledge about data distribution. • Alzheimer's data is classified using various feature extraction methods. • Voxel based and volume based morphometry is utilized for analysis. • Better localization of brain regions is obtained using proposed method. Alzheimer's disease is one of the most common causes of death in today's world. Magnetic resonance imaging (MRI) provides an efficient and non-invasive approach for diagnosis of Alzheimer's disease. Efficient feature extraction techniques are needed for accurate classification of MRI images. Motivated by the work on support vector machine based recursive feature elimination (SVM-RFE) [16] , we propose a novel feature selection technique to incorporate prior information about data distribution in the recursive feature elimination process. Our method is termed as universum support vector machine based recursive feature elimination (USVM-RFE). The proposed method provides global information about data in the RFE process as compared to the local approach of feature selection in SVM-RFE. We also present the application of feature selection and classification algorithms on both voxel based as well as volume based morphometry analysis of structural MRI images (ADNI database). Feature selection is performed using MRI data of brain tissues such as gray matter, white matter, and cerebrospinal fluid. USVM-RFE provides improvement over SVM-RFE in classification of control normal (CN), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects. Moreover, better accuracy is obtained by USVM-RFE with lesser number of features in comparison to SVM-RFE. This leads to identification of prominent brain regions for feature selection and classification of MRI images. The highest accuracies obtained by our method for classification of CN vs AD, CN vs MCI, and MCI vs AD are 100%, 90%, and 73.68%, respectively. [ABSTRACT FROM AUTHOR]