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Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke.
- Source :
- Journal of Clinical Neuroscience; Mar2020, Vol. 73, p215-218, 4p
- Publication Year :
- 2020
-
Abstract
- • Microglia are activated after ischemic stroke and sTREM2 levels are considered to reflect the activation of microglia. • Early increment of sTREM2 and late decrement of sTREM2 were more common in patients with poor outcome after ischemic stroke. • Early increment of sTREM2 were independently associated with poor outcome after ischemic stroke. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outcome. The results from the present study indicate that increment of sTREM2 level at the early phase was a predictor of poor outcome. Serial follow-up of sTREM2 may aid prognosis after stroke. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09675868
- Volume :
- 73
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 142318908
- Full Text :
- https://doi.org/10.1016/j.jocn.2020.02.016