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Methylation of drug resistance‐related genes in chemotherapy‐sensitive Epstein–Barr virus‐associated gastric cancer.

Authors :
Ohmura, Hirofumi
Ito, Mamoru
Uchino, Keita
Okada, Chihiro
Tanishima, Shigeki
Yamada, Yuichi
Momosaki, Seiya
Komoda, Masato
Kuwayama, Miyuki
Yamaguchi, Kyoko
Okumura, Yuta
Nakano, Michitaka
Tsuchihashi, Kenji
Isobe, Taichi
Ariyama, Hiroshi
Kusaba, Hitoshi
Oda, Yoshinao
Akashi, Koichi
Baba, Eishi
Source :
FEBS Open Bio; Jan2020, Vol. 10 Issue 1, p147-157, 11p
Publication Year :
2020

Abstract

Epstein–Barr virus (EBV)‐associated gastric cancer (GC) is associated with a high degree of DNA methylation. However, the association between chemotherapy susceptibility and tumor DNA methylation in advanced diseases remains unclear. The comprehensive DNA methylation status of GC cells obtained from an advanced EBV‐associated GC (EBVGC) case, in which complete response to S‐1 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, ABCG2, AHNAK2, BCL2, FZD1, and TP73 are associated with published evidence for resistance to 5‐fluorouracil and cisplatin. Silencing of these genes may be associated with hypersensitivity to chemotherapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22115463
Volume :
10
Issue :
1
Database :
Supplemental Index
Journal :
FEBS Open Bio
Publication Type :
Academic Journal
Accession number :
141076506
Full Text :
https://doi.org/10.1002/2211-5463.12765