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Cytology Versus Histology in the Primary Diagnosis of Lymphoma Located in the Mediastinum.
- Source :
- Annals of Thoracic Surgery; Jul2019, Vol. 108 Issue 1, p244-248, 5p
- Publication Year :
- 2019
-
Abstract
- Endobronchial ultrasound–guided transbronchial needle aspirations (EBUS-TBNAs) are well established for staging lung cancer. A growing number of publications report on lymphoma diagnosis via EBUS-TBNA–acquired cytology; however current guidelines recommend histologic diagnosis. Research on the value of EBUS-TBNA–acquired cytology versus surgical-acquired histology in the diagnosis of lymphoma is lacking. We conducted a retrospective review of patients with mediastinal lymphoma diagnosed between 2010 and 2016. Mediastinal lymphadenopathy was accessible through both EBUS-TBNAs and surgical procedures. All data were extracted from our clinic's medical database and analyzed. Fifty-one patients newly diagnosed with lymphoma in the mediastinum were identified (median age, 43.5 years; mean age, 48.6 ± 20.6 years). A minimally invasive procedure was performed as a first diagnostic step in 29 patients, whereas surgical biopsy was performed in the remaining 22. The time to final diagnosis was significantly longer if a minimally invasive procedure was performed first compared with a surgical procedure (mean, 44 days [median, 38 days] vs 16 days [median, 8 days]; p < 0.030). The number of procedures to obtain a final diagnosis ranged from one to five (median, 2 procedures per patient) in the EBUS-TBNA group. This was significantly higher than that in the surgical group (median, 1 procedure per patient; p < 0.00005). We demonstrate that surgical biopsies are safe and well tolerated for lymphoproliferative disease diagnosis and lead to a final diagnosis in the shortest possible time. Unnecessary procedures were significantly reduced if a surgical biopsy was performed as the first step. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00034975
- Volume :
- 108
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Annals of Thoracic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 137095641
- Full Text :
- https://doi.org/10.1016/j.athoracsur.2019.02.030