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Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma.
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Apr2019, Vol. 127 Issue 4, p272-281, 10p
- Publication Year :
- 2019
-
Abstract
- <bold>Objective: </bold>Rhabdomyosarcoma (RMS) represents the most common soft tissue sarcoma that affects children. Treatment involves chemoradiotherapy. This study aimed at evaluating the long-term alterations to teeth and cranial bones in children, teenagers, and young adults after oncologic treatment.<bold>Study Design: </bold>We conducted a cross-sectional study of patients undergoing treatment for head and neck RMS between 1988 and 2011. We evaluated demographic, clinical, and treatment data and performed panoramic radiography, cephalometry, and photography.<bold>Results: </bold>We evaluated 27 long-term survivors, most of whom had been treated between ages 0 to 5 years (51.9%). The total radiation dose applied was 50.4 Gy, and the chemotherapy combination included vincristine, actinomycin D, and cyclophosphamide in 51.9% of the cases. We observed 603 dental alterations, among which 377 (62.7%) occurred in patients ages 0 to 5 years, and root shortening was the most frequent alteration observed (24.2%). With regard to facial bones, 74% of the patients had some level of facial asymmetry, 70.4% had reduced facial depth, 48.4% had mandibles of short size, and 77.8% had reduced facial height.<bold>Conclusions: </bold>Children submitted to RMS treatment involving chemotherapy and radiotherapy displayed significant dental and craniofacial alterations, especially when treatment occurred between ages 0 and 5 years. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124403
- Volume :
- 127
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 135531853
- Full Text :
- https://doi.org/10.1016/j.oooo.2018.12.012