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Platycodon grandiflorum Saponins attenuate scrotal heat-induced spermatogenic damage via inhibition of oxidative stress and apoptosis in mice.

Authors :
Leng, Jing
Hou, Jin-gang
Fu, Cheng-lin
Ren, Shen
Jiang, Shuang
Wang, Ying-ping
Chen, Chen
Wang, Zi
Li, Wei
Source :
Journal of Functional Foods; Mar2019, Vol. 54, p479-488, 10p
Publication Year :
2019

Abstract

Graphical abstract Highlights • Platycodon grandiflorum Saponins (PGS) ameliorated scrotal heat-induced spermatogenic damage in mice. • Platycodon grandiflorum Saponins (PGS) inhibited heat stress (HS)-induced oxidative stress and apoptosis in mice. • Platycodon grandiflorum Saponins (PGS) partly regulated the MAPK signaling pathway in HS mice. Abstract The aim of the present study was designed to investigate that Platycodon grandiflorum saponins (PGS) exerted protective effects against testicular injury induced by scrotal hyperthermia. PGS (15, 30 mg/kg) were administered intragastrically to mice for 14 days, then exposed to a single scrotal heat treatment at 43 °C for 18 min on the 7th day. Heat stress (HS) induced spermatogenic damage was associated with a significant loss of leydig cells and the changes of serum testosterone, oxidative stress and apoptosis markers, and activated MAPK signaling pathway. In contrast, PGS treatment normalized HS-induced histopathological changes and prevented the activation of MAPK signaling pathway, which was contributed to oxidative stress and apoptosis in the testis of treated mice. In conclusion, our findings clearly demonstrated that PGS exhibited a significant protective effect against HS-induced testicular dysfunction, largely dependent upon the inhibition of oxidative stress associated apoptosis via partly regulation of MAPK signaling pathway. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17564646
Volume :
54
Database :
Supplemental Index
Journal :
Journal of Functional Foods
Publication Type :
Academic Journal
Accession number :
135291518
Full Text :
https://doi.org/10.1016/j.jff.2019.01.050