Total Circulating Microparticle Levels After Laparoscopic Surgical Treatment for Endometrioma: A Pilot, Prospective, Randomized Study Comparing Stripping with CO2 Laser Vaporization.

<bold>Study Objective: </bold>To evaluate serial generation of microparticles (MPs) after laparoscopic stripping or CO2 laser vaporization in the surgical treatment of patients with ovarian endometrioma (OE).<bold>Design: </bold>A prospective, randomized, blinded, pilot study (Canadian Task Force classification I).<bold>Setting: </bold>Tertiary care university hospital from December 2014 to July 2016.<bold>Patients: </bold>Thirty women with unilateral OE undergoing laparoscopic surgery.<bold>Intervention: </bold>Patients were randomly selected to undergo either CO2 laser vaporization (L group) or laparoscopic stripping (S group) of OE.<bold>Measurements and Main Results: </bold>Blood samples were collected before surgery and at 2 hours, 24 hours, 1 month, and 3 months after surgery. An MP generation curve after OE surgery was created. MP generation was greater in the S group than in the L group at all time points evaluated. The MP generation curve showed a significantly higher area under the curve after excisional surgery (p <.05).<bold>Conclusion: </bold>The higher MP levels in the S group suggest an increased inflammation and procoagulant response after this procedure. [ABSTRACT FROM AUTHOR]