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Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion.
- Source :
- Neurological Research; Jan2014, Vol. 36 Issue 1, p70-78, 9p
- Publication Year :
- 2014
-
Abstract
- The aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (TRPV4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (DRG) (hereafter termed CCD) in rat. Intrathecal administration of microtubule-depolymerizing agent, colchicine, attenuated the activated effect of 4alphaphorbol 12, 13-didecanoate (4alpha-PDD, TRPV4 specific agonist) on mechanical and thermal hyperalgesia in CCD rats. This observation is in agreement with our in vitro experiments with DRG cells that showed a significant attenuation of 4alpha-PDD-activated Ca<superscript>2+</superscript>-influx and substance P (SP) release with the colchicine treatment. We conclude that microtubule depolymerization by colchicine can regulate pain sensitivity by depressing the hyperalgesia mediated by TRPV4. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERALGESIA
DORSAL root ganglia
COLCHICINE
TRP channels
LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 01616412
- Volume :
- 36
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Neurological Research
- Publication Type :
- Academic Journal
- Accession number :
- 132902942
- Full Text :
- https://doi.org/10.1179/1743132813Y.0000000261