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Impact of regional white matter lesions on cognitive function in subcortical vascular cognitive impairment.
- Source :
- Neurological Research; May2014, Vol. 36 Issue 5, p434-443, 10p
- Publication Year :
- 2014
-
Abstract
- Objective: Previous studies have shown that diabetes increases the prevalence of arterial stiffness. However, it remains controversial whether impaired fasting glucose (IFG), a key pre-diabetes condition, is associated with increased risk of arterial stiffness. This study aimed to investigate the relationship between increased fasting plasma glucose (FPG) and the prevalence of arterial stiffness in a Chinese adult population. Methods: A random sample of 5039 participants aged 40 years or older (40.0% female) were enrolled in this study. Information on potential risk factors for cardiovascular disease was collected, and the presence of arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Participants were stratified into three groups: normal fasting glucose (NFG), IFG, and diabetes mellitus (DM). The IFG group was further stratified by quartiles based on the level of FPG into Q1, Q2, Q3, and Q4. Results: Fasting plasma glucose level was found to be independently and positively associated with baPWV. The adjusted odds ratios (ORs) (95% confidence interval (CI)) for arterial stiffness were 1.09 (0.80-1.48), 1.33 (0.98-1.81), 1.27 (0.93-1.73), 1.82 (1.31-2.53), and 2.15 (1.66-2.79) for those in IFG Q1, Q2, Q3, Q4, and DM groups compared with NFG group (P < 0.001), respectively, after adjusting for age, sex, and other potential confounders. Moreover, male participants and participants younger than 60 years were closely associated with the presence and severity of arterial stiffness (P < 0.001). Conclusion: Our study reports a previously unidentified positive association between increased FPG and the prevalence of arterial stiffness, suggesting the importance of FPG control in the prevention of arterial stiffness. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIABETES
COGNITIVE ability
WHITE matter (Nerve tissue)
BLOOD sugar
ARTERIES
Subjects
Details
- Language :
- English
- ISSN :
- 01616412
- Volume :
- 36
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Neurological Research
- Publication Type :
- Academic Journal
- Accession number :
- 132878784
- Full Text :
- https://doi.org/10.1179/1743132814Y.0000000354