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Acidic mammalian chitinase gene is highly expressed in the special oxyntic glands of Manis javanica.
- Source :
- FEBS Open Bio; Aug2018, Vol. 8 Issue 8, p1247-1255, 9p
- Publication Year :
- 2018
-
Abstract
- The Malayan pangolin (Manis javanica) is a mammal that feeds primarily on ants and termites, which contain the energy‐rich carbohydrate chitin. Chitin is digestible by endogenous enzymes of the typical mammalian gastrointestinal tract, especially the acidic mammalian chitinase (AMCase). The objective of this research was to determine whether AMCase activity is expressed in the stomach of M. javanica. The stomach tissues were divided into three parts: the gastric sack, the oxyntic glands, and the pyloric musculature, which were assayed by conventional RT‐PCR, quantitative reverse transcriptase‐coupled PCR (qPCR) and western blot. Information regarding 3D structural models of AMCase was also obtained. In conclusion, acidic mammalian chitinase is highly expressed in the oxyntic glands of the M. javanica species. [ABSTRACT FROM AUTHOR]
- Subjects :
- MALAYAN pangolin
CHITINASE genetics
MAMMALS
PARIETAL cells
GLANDS
Subjects
Details
- Language :
- English
- ISSN :
- 22115463
- Volume :
- 8
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- FEBS Open Bio
- Publication Type :
- Academic Journal
- Accession number :
- 131033472
- Full Text :
- https://doi.org/10.1002/2211-5463.12461