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Short Communication: Characterization of a New HIV-1 Group N Isolate Originating from a Cameroonian Patient.

Authors :
Tagnouokam Ngoupo, Paul Alain
Sadeuh-Mba, Serge Alain
De Oliveira, Fabienne
Ngo-Malabo, Elodie Téclaire
Ngono, Laure
Plantier, Jean-Christophe
Kfutwah, Anfumbom
Njouom, Richard
Source :
AIDS Research & Human Retroviruses; Jul2018, Vol. 34 Issue 7, p621-625, 5p
Publication Year :
2018

Abstract

HIV-1 group N (HIV-1/N) remains rare and mainly restricted to Cameroon. In this study, we report a new HIV-1/N infected case identified during routine HIV screening activities in Yaounde. The genetic characterization of the near full-length genome of this virus strain revealed that it is genetically distinct to all HIV-1/N described to date. However, the Vpu protein responsible for tetherin antagonism displayed the same amino acid substitutions (E15A, V19A, I25L, and V26L) as other HIV-1/N from Cameroon. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08892229
Volume :
34
Issue :
7
Database :
Supplemental Index
Journal :
AIDS Research & Human Retroviruses
Publication Type :
Academic Journal
Accession number :
130454711
Full Text :
https://doi.org/10.1089/aid.2018.0015