Nano Pt@ZIF8 Modified Electrode and Its Application to Detect Sarcosine.

Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer. [ABSTRACT FROM AUTHOR]