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The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM).
- Source :
- BioMedicine; Mar2018, Vol. 8 Issue 1, p1-11, 11p
- Publication Year :
- 2018
-
Abstract
- Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22118020
- Volume :
- 8
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- BioMedicine
- Publication Type :
- Academic Journal
- Accession number :
- 129065625
- Full Text :
- https://doi.org/10.1051/bmdcn/2018080101