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I3-Ag85 effect on phthiodiolone dimycocerosate synthesis.

Authors :
Rens, Céline
Laval, Françoise
Wattiez, Ruddy
Lefèvre, Philippe
Dufrasne, François
Daffé, Mamadou
Fontaine, Véronique
Source :
Tuberculosis (14729792); Jan2018, Vol. 108, p93-95, 3p
Publication Year :
2018

Abstract

The multiplicity of drug resistant Mycobacterium tuberculosis (Mtb) strains is a growing health issue. New therapies are needed, acting on new targets. The I3-Ag85 was already reported to reduce the amount of trehalose dimycolate lipid of the mycobacterial cell wall. This inhibitor of Ag85C increased the mycobacterial wall permeability. We previously showed that M. tuberculosis strains, even multi-drug resistant and extensively-drug resistant strains, can be susceptible to vancomycin when concomitantly treated with a drug altering the cell envelope integrity. We investigated the effect of the I3-Ag85 on vancomycin susceptibility of M. tuberculosis . Although no synergy was observed, a new target of this drug was discovered: the production of phthiodiolone dimycocerosate (PDIM B). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14729792
Volume :
108
Database :
Supplemental Index
Journal :
Tuberculosis (14729792)
Publication Type :
Academic Journal
Accession number :
128415393
Full Text :
https://doi.org/10.1016/j.tube.2017.10.007