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Impulse control disorder and response-inhibition alterations in Parkinson’s disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature.
- Source :
- Journal of Advanced Research; Nov2017, Vol. 8 Issue 6, p713-716, 4p
- Publication Year :
- 2017
-
Abstract
- This report illustrates a Parkinson’s disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go , which signifying that a hypo-function of this network could be associated with ICD. A fronto-striatal and cingulo-frontal dysfunction may reflect impairment in metacognitive-executive abilities (such as response-inhibition, action monitoring, and error awareness) and promote compulsive repetition of behavior. Response-inhibition tasks may be useful in PD post-diagnostic phase, to better identify individuals at risk of developing ICD with dopaminergic medication. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20901232
- Volume :
- 8
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Advanced Research
- Publication Type :
- Academic Journal
- Accession number :
- 126231763
- Full Text :
- https://doi.org/10.1016/j.jare.2017.09.004