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Assessing the toxicity of triphenyltin to different life stages of the marine medaka Oryzias melastigma through a series of life-cycle based experiments.
- Source :
- Marine Pollution Bulletin; Nov2017, Vol. 124 Issue 2, p847-855, 9p
- Publication Year :
- 2017
-
Abstract
- Toxic effects of triphenyltin (TPT) to different life stages of the marine medaka Oryzias melastigma were investigated through a series of life-cycle based exposure experiments. In embryo stage, TPT exposure could elevate the heartbeat rate at Day 6–8 post-fertilization and increase the expression levels of five heart development related genes (i.e., ATPase , COX2 , BMP4 , GATA4 and NKX2.5 ). In larval stage, TPT shortened the body length at ≥ 10 μg/L and suppressed the swimming activity of the fish larvae at Day 1 post-hatching at 50 μg/L. In reproductive stage, TPT exposure resulted in a male-biased sex ratio (2 μg/L) and reduced the gonadosomatic index (GSI) in females (≥ 0.1 μg/L), which might in turn lead to a decline in their population fitness. The reproductive stage of O. melastigma was more sensitive to TPT than other stages, while the GSI of female medaka was the most sensitive endpoint. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0025326X
- Volume :
- 124
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Marine Pollution Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 126121402
- Full Text :
- https://doi.org/10.1016/j.marpolbul.2017.02.030