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Two-level diagnostic classification using cerebrospinal fluid YKL-40 in Alzheimer's disease.
- Source :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Sep2017, Vol. 13 Issue 9, p993-1003, 11p
- Publication Year :
- 2017
-
Abstract
- Introduction We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) YKL-40 in discriminating (1) clinical Alzheimer's disease (AD) from cognitively healthy controls (HCs) and frontotemporal dementia (FTD) (level I) and (2) patients stratified by different pathophysiological profiles from HCs and FTD following a novel unbiased/descriptive categorization based on CSF biomarkers, independent of cognitive impairment severity (level II). Methods YKL-40 was compared among HCs ( n = 21), mild cognitive impairment ( n = 41), AD ( n = 35), and FTD ( n = 9) (level I) and among HCs ( n = 21), AD pathophysiology (tau and amyloid β) negative ( n = 15), tau positive ( n = 15), amyloid β positive ( n = 13), AD pathophysiology positive ( n = 33), and FTD ( n = 9) (level II). Results Level I: YKL-40 discriminated AD from HC and FTD (area under the receiver operating characteristic curves [AUROCs] = 0.69, 0.71). Level II: YKL-40 discriminated tau-positive individuals and AD pathophysiology–positive individuals from HC, AD pathophysiology–positive patients from FTD (AUROCs = 0.76, 0.72, 0.73). Discussion YKL-40 demonstrates fair performance in distinguishing tau-positive patients from HCs, suggesting it may aid clinical diagnosis and support a biomarker-guided pathophysiological stratification. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15525260
- Volume :
- 13
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 124952313
- Full Text :
- https://doi.org/10.1016/j.jalz.2017.01.021