Substituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation.

We have developed a novel method for synthesis of various kinds of nitroarenes by using a three-component ring transformation (TCRT) of dinitropyridone with ketones in the presence of ammonium acetate as nitrogen source. This method requires only simple manipulations and mild reaction conditions. Furthermore, the modification of obtained nitropyridine or nitroaniline frameworks can be easily obtained only changing a commercially available substrates. [ABSTRACT FROM AUTHOR]