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A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells.
- Source :
- Ecotoxicology & Environmental Safety; Mar2017, Vol. 137, p179-185, 7p
- Publication Year :
- 2017
-
Abstract
- The cytotoxic potential of 13 commonly used agricultural insecticides was examined using cell-based systems with three human HepG2, Hek293, HeLa cells and three insect Tn5B1-4, Sf-21, and Drosophila S2 cells. Data showed that (1) an enhancement of some insecticides (e.g. pyrethroids) on cells proliferation; (2) an inhibition of some insecticides on cells viability; (3) various levels of susceptibility of different cells to the same insecticide; and (4) the cell type dependent sensitivity to different insecticides. The degree of cytotoxicity of insecticides on human cells was significantly lower than that on insect cells ( P <0.05). Methomyl, even 20 μg/ml, showed little cytotoxicity at 24 h exposure whereas emamectin benzoate possessed the strongest cytotoxic potential in a dose-dependent fashion. The results revealed comparable cytotoxic property of agricultural insecticides against intact cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01476513
- Volume :
- 137
- Database :
- Supplemental Index
- Journal :
- Ecotoxicology & Environmental Safety
- Publication Type :
- Academic Journal
- Accession number :
- 120524553
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2016.12.002