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Whey protein hydrolysates enhance water absorption in the perfused small intestine of anesthetized rats.
- Source :
- Bioscience, Biotechnology & Biochemistry; Aug2016, Vol. 80 Issue 8, p1587-1593, 7p
- Publication Year :
- 2016
-
Abstract
- We evaluated the effect of whey protein hydrolysates (WPH) on the water absorption rate in the small intestine using a rat small intestine perfusion model. The rate was significantly higher with 5 g/L WPH than with 5 g/L soy protein hydrolysates or physiological saline (p < 0.05). WPH dose-dependently increased the water absorption rate in the range of 1.25–10.0 g/L. WPH showed a significantly higher rate than an amino acid mixture whose composition was equal to that of WPH (p < 0.05). The addition of 4-aminomethylbenzoic acid, an inhibitor of PepT1, significantly suppressed WPH’s enhancement of water absorption (p < 0.05). The rate of water absorption was significantly correlated with that of peptides/amino acids absorption in WPH (r = 0.82,p < 0.01). These data suggest that WPH have a high water absorption-promoting effect, to which PepT1 contributes. Whey protein hydrolysates promote water absorption in the rat small intestine and PepT1 is suggested to contribute to this effect. [ABSTRACT FROM PUBLISHER]
- Subjects :
- PROTEIN hydrolysates
WATER analysis
AMINO acid synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 09168451
- Volume :
- 80
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Bioscience, Biotechnology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 116344954
- Full Text :
- https://doi.org/10.1080/09168451.2016.1166931