Synthesis of the Butanamide Derivative S 19812, a New Dual Inhibitor of Cyclooxygenase and Lipoxygenase Pathways.

Authors :: Tordjman, Charles
Sauveur, Frederic
Droual, Monique
Briss, Sylvie
Andre, Nathalie
Bellot, Isabelle
Deschamps, Christine
Wierzbicki, Michel
Source :: Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften); Nov2003, Vol. 53 Issue 11, p774-779, 6p, 3 Diagrams, 1 Chart, 2 Graphs
Publication Year :: 2003
Abstract: Investigates the general synthetic pathway and the interactions with arachidonic acid metabolism of hydroxy-N-methyl 4-(2,3-bis-(4-methoxy-phenyl)-thiophen-5-yl)butanamide. Dual inhibition of cyclooxygenase and 5-lipoxygenase pathways in vitro in rat polymorphonuclear neutrophils and ex vivo in mice blood; Melting points; Pharmacology.

Language :: English
ISSN :: 00044172
Volume :: 53
Issue :: 11
Database :: Supplemental Index
Journal :: Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften)
Publication Type :: Academic Journal
Accession number :: 11530762

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