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Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles.

Authors :
Mariappan, Leo
Shao, Qi
Jiang, Chunlan
Yu, Kai
Ashkenazi, Shai
Bischof, John C.
He, Bin
Source :
Nanomedicine: Nanotechnology, Biology & Medicine; Apr2016, Vol. 12 Issue 3, p689-699, 11p
Publication Year :
2016

Abstract

Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body. From the Clinical Editor Many magnetic nanoparticles (MNPs) have been used as contrast agents in magnetic resonance imaging. In this study, the authors investigated the use of ultrasound to detect the presence of MNPs by magneto acoustic tomography. In-vivo experiments confirmed the imaging quality of this new approach, which hopefully would provide an alternative method for accurate tumor detection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15499634
Volume :
12
Issue :
3
Database :
Supplemental Index
Journal :
Nanomedicine: Nanotechnology, Biology & Medicine
Publication Type :
Academic Journal
Accession number :
114013010
Full Text :
https://doi.org/10.1016/j.nano.2015.10.014