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Adjuvant Chemotherapy for Endometrial Cancer.

Authors :
Creutzberg, Carien L.
Source :
International Journal of Gynecological Cancer; Oct2010, Vol. 20 Issue 7, p1105-1108, 4p
Publication Year :
2010

Abstract

High-risk endometrial cancer (EC), only 15% of all EC, mainly affects elderly women, often with significant comorbid diseases. Because patients with high-risk EC are at increased risk of distant metastases and EC death, the use of adjuvant chemotherapy has been investigated in several trials. Trials comparing radiotherapy and chemotherapy have not shown survival difference. A first trial comparing combinations of chemotherapy and radiotherapy with radiotherapy alone suggested progression-free survival benefit. Toxicity and quality of life data are lacking. The role of adjuvant chemotherapy for endometrial carcinoma remains unproven. High-risk EC remains the challenge for further research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1048891X
Volume :
20
Issue :
7
Database :
Supplemental Index
Journal :
International Journal of Gynecological Cancer
Publication Type :
Academic Journal
Accession number :
113081034
Full Text :
https://doi.org/10.1111/IGC.0b013e3181f35473