Primary fallopian tube carcinoma: the prognostic impact of stage, histopathology and biological parameters.

Short- and long-time survivors among patients with primary fallopian tube carcinoma (PFTC) were studied with respect to prognosis predicting factors. Within the Radiumhemmets series 35 patients died within 2 years and they were compared with 27 patients surviving 8 years or more. All tumours were aneuploid. The two groups had different p53 immunoreactivity (P = 0.05). The prognostic influence of FIGO stage, proliferative activity(MIB-I), tumor angiogenesis (F8) and p53 immunoreactivity was studied in all stages. MIB-1, F8, and p53 immunoreactivity showed no significant correlation to survival. FIGO stage was significantly correlated to survival(P = 0.001). Increasing proliferative activity correlated to poor survival in a multivariate analysis of stage I (P = 0.015). Nine out of 19 stage I patients are still alive with a median survival of 22 years(11-32). Six of the survivors (66%) did not receive chemotherapy and underwent incomplete surgery. Two patients in stage IV are still alive after 12 and 13 years respectively. The only difference in biological parameters in the two survival groups was the absence of p53 mutations in the long-time survivors. [ABSTRACT FROM AUTHOR]