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Clinicopathologic features, microvessel density, and immunohistochemical expression of ICAM-1 and VEGF in 15 cases of secondary syphilis with oral manifestations.
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Mar2016, Vol. 121 Issue 3, p274-281, 8p
- Publication Year :
- 2016
-
Abstract
- <bold>Background: </bold>Several studies have reported the clinical aspects of oral syphilis, but few papers have considered the involved immunoinflammatory mechanisms.<bold>Objective: </bold>To analyze the clinicopathologic features and expression of immunoinflammatory and vascular proteins in oral secondary syphilis.<bold>Study Design: </bold>Fifteen patients with oral secondary syphilis were included; histologic features were analyzed using hematoxylin-eosin-stained histologic slides and immunohistochemical reactions were performed against intercellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and CD34.<bold>Results: </bold>Lesions presented as multiple plaques and ulcers mostly located on the tongue, lips, and palate. They were covered by a stratified epithelium of irregular thickness showing exocytosis associated with a subjacent plasma cell infiltrate arranged in perivascular and perineural patterns. ICAM-1 and VEGF were expressed on endothelial cells and leukocytes, and microvessel density was similar on the superficial and deep regions of the connective tissue.<bold>Conclusions: </bold>Expression of immunoinflammatory and vascular proteins was intense, suggesting their participation on the pathogenesis of oral secondary syphilis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124403
- Volume :
- 121
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 112849136
- Full Text :
- https://doi.org/10.1016/j.oooo.2015.09.022