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Abstract 219.
- Source :
- Hypertension (0194911X); 2014 Supplement, Vol. 64, pA219-A219, 1p
- Publication Year :
- 2014
-
Abstract
- Current models of essential hypertension are limited in comparisons to human pathophysiology due to distinct differences in postural positioning, circadian rhythmicity, and genetic variation. We have identified a unique non-human primate model of spontaneous, essential hypertension in Chlorocebus aethiops sabaeus, the African Green, or vervet, monkey. Using forearm plethysmography under light ketamine sedation (~15mg/kg), adult vervets were categorized as hypertensive (HT; SBP >140mmHg), borderline hypertensive (BHT; 120mmHg < SBP < 140mmHg), or normotensive (NT; SBP < 120 mmHg). Of the 168 males phenotyped, 32% (53 of 168) were HT (average SBP = 168.79±3.29mmHg), 27% (45 of 168) were BHT (average SBP = 129.58±0.88mmHg), and 41% (70 of 168) were NT (average SBP = 100.21±1.65mmHg). In a smaller study of 18 adult females, 1 was found to be HT (SBP = 156mmHg), 2 were BHT (average SBP = 134±2.0mmHg), and 15 were NT (average SBP = 98.06±4.32mmHg). Fixed paraffin-embedded histological sections of vervet cardiac (H&E) and renal (periodic acid Schiff) tissues were digitized and analyzed. Wall/lumen ratios of renal arterioles (average diameter 33.01±0.5μm) were greater in HT (0.33±0.03) compared to NT (0.24±0.01) male monkeys. Bowman’s capsule space was increased in HT (43.14±3.98% area) glomeruli compared to NT (29.92±2.42% area) glomeruli (p<0.05). Indicative of left ventricular hypertrophy, left ventricular cells were decreased in HT (1833.33±65.48 cells/mm<superscript>2</superscript>) compared to NT monkeys (2223.61±59.72 cells/mm<superscript>2</superscript>; p<0.05). The increased wall/lumen ratios and Bowman’s capsular spaces indicate that renal vascular hypertrophy and glomerular damage occur in this non-human primate model of essential hypertension. Left ventricular hypertrophy combined with renal glomerular and vascular dysfunction provides strong evidence for using this non-human primate model as a translational experimental species. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0194911X
- Volume :
- 64
- Database :
- Supplemental Index
- Journal :
- Hypertension (0194911X)
- Publication Type :
- Academic Journal
- Accession number :
- 112493640