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Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia.
- Source :
- Journal of the Formosan Medical Association; Jan2016, Vol. 115 Issue 1, p38-44, 7p
- Publication Year :
- 2016
-
Abstract
- <bold>Background/purpose: </bold>Lipid metabolism is involved in beta amyloid generation, which has been related with the progression of Alzheimer's disease (AD). No study has explored the association between polymorphisms of SAR1 homolog B (SAR1B) and the risk of dementia previously.<bold>Methods: </bold>This is a case-control study. A total of 279 AD and 117 vascular dementia (VaD) patients were recruited from neurology clinics at three teaching hospitals in Taiwan from 2007 to 2010. Controls (n = 466) were recruited from the elderly health checkup program and volunteers in the hospital during the same time interval. Three common (frequency ≥ 5%) haplotype-tagging single nucleotide polymorphisms were selected from the lipid metabolism gene SAR1B to assess its association with AD and VaD.<bold>Results: </bold>Homozygous variants of rs11948613 were associated with a decreased AD risk (CC vs. TT: adjusted odds ratio = 0.39, 95% confidence interval = 0.15-0.98) with a population attributable risk of 26.7%. This association decreased further in apolipoprotein E ε4 (ApoE ε4) noncarriers (adjusted odds ratio = 0.28, 95% confidence interval = 0.09-0.91). No association was found for VaD. Two common haplotypes (with a cumulative frequency of 95.7% in controls) were identified for SAR1B, and no association was found for AD or VaD. Simultaneous screening using rs11948613 and ApoE ε4 significantly improved the sensitivity of ApoE ε4 alone (from 0.40 to 0.75).<bold>Conclusion: </bold>SAR1B polymorphisms were associated with AD risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE ε4 status offered a better sensitivity for AD screening. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALZHEIMER'S disease risk factors
VASCULAR dementia
GENETIC polymorphisms
LIPID metabolism
DISEASE progression
PERIODIC health examinations
DISEASE risk factors
ALLELES
ALZHEIMER'S disease
APOLIPOPROTEINS
CARRIER proteins
COMPARATIVE studies
DISEASE susceptibility
GENES
GENETIC disorders
LIPID metabolism disorders
RESEARCH methodology
MEDICAL cooperation
MULTIVARIATE analysis
RESEARCH
LOGISTIC regression analysis
EVALUATION research
CASE-control method
HAPLOTYPES
ODDS ratio
GENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 115
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of the Formosan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 112311143
- Full Text :
- https://doi.org/10.1016/j.jfma.2015.01.008